The Macromolecule and Vaccine Stabilization Center is a unique and innovative biotechnology center located within the Department of Pharmaceutical Chemistry at the University of Kansas.

Our goal is to improve the stability of proteins, DNA, macromolecular assemblies, virus-like particles, viruses, and bacterial cells for pharmaceutical use.

Our approach focuses on molecular events associated with changes in physical and chemical stability that lead to loss of activity or function.

Our services range from complete preformulation and formulation studies to simple biophysical and biochemical characterization of potential biopharmaceuticals and vaccines.

  • Preformulation and formulation studies
  • Biophysical characterization of macromolecules and vaccines
  • Physical stability
  • Chemical stability
  • Additional analytical characterization packages
  • Diverse problem solving

Our laboratories with state-of-the-art instruments are housed in the Multidisciplinary Research Building on the University of Kansas West Campus in Lawrence, and occupy 10,000 sq ft of modern laboratory space. A state-of-the-art Biological Safety Level 3 laboratory fully equipped for macromolecular formulation studies and an adjacent tissue culture facility are an integral part of the laboratory. We also have access to other KU facilities, including high resolution NMR (800 MHz), X-ray crystallography, mass spectrometry, microscopy, and protein production.  Additional analytical characterization studies are carried out in collaboration with other KU laboratories.

Contact Information

Head, David B. Volkin PhD

2030 Becker Drive
Lawrence, KS 66047

Director, Sangeeta B. Joshi PhD

2030 Becker Drive
Lawrence, KS 66047

Scientific Advisor, C. Russell Middaugh PhD

2030 Becker Drive
Lawrence, KS 66047