Equipment


Spectroscopy

Key equipment

  • Applied Photophysics Chirascan-plus ACD (Automated Circular Dichroism) (pictured)
  • PTI Steady-State and Lifetime Fluorometer (3) (pictured)
  • Bruker Vertex 70 FTIR Spectrometer (pictured)
  • Applied Photophysics Chirascan Plus (2)
  • Agilent 8453 UV-Vis Spectrophotometer (2)
  • Bruker Tensor 27 FTIR Spectrometer
  • Cary 100 Bio UV-Visible Spectrophotometer
  • Fluorescence Innovations Lifetime Fluorometer (384 well plate)

Additional Capabilities

  • Olis Clarity UV-Vis
  • Ultrasonic Scientific HR-US 102 Ultrasonic Spectrometer
  • Agilent Stratagene Mx3005P QPCR System
  • Horiba T-6400 UV-Raman Spectrophotometer


Immunoassays

  • Forte Bio Octet Red96 multichannel Bio-Layer Interferometry System  (pictured)
  • BioTek automated plate washer for ELISA  (pictured)
  • SpectraMax M5 microtiter plate reader for ELISA
  • Forte Bio BLItz single channel Bio-Layer Interferometry System


Light Scattering

  • Wyatt DynaPro Plate Reader (pictured)
  • Wyatt Dawn Heleos II Multi-Angle Light Scattering Detector (Batch measurements and in-line HPLC detection) (pictured)
  • Wyatt Calypso Gradient Mixer (for CG-MALS capabilities) (pictured)
  • Brookhaven ZetaPALS Zeta Potential Analyzer


Calorimetry

  • Microcal High Throughput Differential Scanning Calorimeter (2) (pictured)
  • MicroCal Auto-Isothermal Titration Calorimeter (ITC)
  • TA Instruments Q100 Differential Scanning Calorimeter and Q50 Therrmogravimetric Analyzer


Chromatography, Electrophoresis and Analytical Ultracentrifugation

  • Protein Simple iCE3 (pictured)
  • Thermo UHPLC (pictured)
  • Beckman-Coulter ProteomeLab XL-I Analytical Ultracentrifuge (pictured)
  • Agilent UHPLC
  • Shimadzu HPLC (4) (UV, Fluorescence, Light Scattering and RI detectors available)
  • Convergent Bioscience iCE280 Fast IEF Analyzer
  • Thermo-Scientific UHPLC
  • Amersham Pharmacia Biotech AKTA FPLC System
  • Alpha Imager Gel Imaging System


Pharmaceutical (e.g., densitometers, viscometers, refractometers)

  • Wyatt Optilab rEX differential refractometer
  • Anton Paar High Sensitivity Density Meter (2)
  • Rheosense m-VROC viscometer
  • Anton Paar Viscometer

Particle Analysis

  • Protein Simple MFI DPA-5200 w/autosampler (pictured)
  • Nanosoight LM-10HS nanoparticle tracking system
  • Bruker Vertex 70 FTIR Microscope
  • Malvern Archimedes Particle Metrology System


 


Mass Spectrometry

  • Thermo LTQ XL Mass Spectrometer w/Thermo UHPLC (Fluorescence and UV detection) (pictured)
  • Agilent Q-TOF Mass Spectrometer w/Agilent HPLC
  • Agilent CE-SDS and IEF system for in-line or offline use w/Q-TOF


Lyophilization Lab

  • FTS Lyo Star II  (pictured)
  • FTS Virtis Advantage Plus-EL Benchtop Lyophilizer
  • TA Instruments Q100 Differential Scanning Calorimeter and Q50 Therrmogravimetric Analyzer (for Tg and Tg’)
  • Karl Fisher titrator  (Oven method)
  • Karl Fisher titrator (Dry Methanol method)


Live virus potency measurements (in BSL-2 lab)

  • Nikon Eclipse Ti-E Fluorescence Microscope  (pictured)
  • QuantStudio™ 7 Flex Real-Time PCR System (3) (pictured)
  • SpectraMax M3 plate reader

Live virus biophysical and particle characterization assays (in BSL-2 lab)

  • Protein Simple MFI DPA-4200
  • Nanosight LM-10HS nanoparticle tracking system
  • Agilent 8453 UV-Vis spectrometer
  • PTI Steady-State and Lifetime Fluorometer
  • Beckman-Coulter Benchtop and floor preparative Ultracentrifuges